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Avicenna Journal of Medical Biotechnology، جلد ۱۴، شماره ۴، صفحات ۳۱۷-۳۲۰
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عنوان انگلیسی Effects of Poly-N-isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas aeruginosa Isolated from Chronic Wounds
چکیده انگلیسی مقاله Background: Biofilm formation helps Pseudomonas ‎aeruginosa (P. ‎aeruginosa) survive in various environments. Microgels can be effective in treatment of bacterial infections. The major aim of this study was to investigate effects of poly-N-isopropyl-acrylamide microgels (PNIPAM) on P. aeruginosa. Methods: Totally‎, ‎100 P. aeruginosa strains were isolated from chronic wound infections‎. Quantitative assessments of biofilm formation and antibiotic susceptibility were carried out. Furthermore, algD, lasR, and PA2714 genes were amplified to investigate gene frequencies and expression rates. Results: Significant decreases were seen in lasR expression in EDTA-treated samples‎. Significant decreases were observed in expression of algD and lasR treated with xylitol. Decreased ‎expression of PA2714 was seen in samples treated with xylitol with no significance.  Conclusion: The PNIPAM containing xylitol ‎or EDTA could penetrate biofilms of P. aeruginosa and significantly decrease expression of lasR and algD. This can be a novel strategy in the management of chronic wounds.
کلیدواژه‌های انگلیسی مقاله Biofilms, Microgels, Pseudomonas aeruginosa, Real-time PCR
نویسندگان مقاله | Akram Etemadinia
Department of Pathobiology, School of Public Health, Tehran University of Medical Science, Tehran, Iran


| Amir Seyfoori
Department of Biomaterials and Tissue Engineering, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran


| Abbas Rahimi Foroushani
Department of Pathobiology, School of Public Health, Tehran University of Medical Science, Tehran, Iran


| Ramin Mazaheri Nezhad Fard
Food Microbiology Research Center, Tehran University of Medical Science, Tehran, Iran


| Ronak Bakhtiari


نشانی اینترنتی https://www.ajmb.org/En/Article.aspx?id=60520
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