International Journal of Reproductive BioMedicine، جلد ۲۰، شماره ۷، صفحات ۵۴۹-۵۶۰

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عنوان انگلیسی Effect of resistance training with and without vitamin D calcium chitosan nanoparticle supplements on apoptosis markers in ovariectomized rats: An experimental study
چکیده انگلیسی مقاله Background: Hormone therapy is one of the most effective treatments for menopausal disorders, but it may increase the risk of breast cancer, coronary heart disease, and pulmonary embolism. Objective: The present study investigated the effect of resistance training with and without vitamin D calcium (Ca++) chitosan nanoparticles on apoptosis markers in ovariectomized rats. Materials and Methods: 42 female Wistar rats were divided into 7 groups (n = 6/each). One group was assigned as the healthy control to show the induction of menopause. The other 6 groups comprised ovariectomized (OVX) animals including: 1) vitamin D + calcium + chitosan + resistance training, 2) saline + estrogen + resistance training, 3) saline + resistance training, 4) vitamin D + calcium + chitosan, 5) saline + estrogen, and 6) OVX + control. 48 hr after the last intervention, the hippocampus tissue was extracted to measure the BCL-2-associated X (BAX), B-cell lymphoma 2 (BCL-2), and caspase-3 gene expression as well as the percentage of dead cells. Results: OVX rats demonstrated increased BAX gene expression, the ratio of BAX gene expression to BCL-2, caspase-3 gene expression, and percentage of dead cells of hippocampal tissue, but decreased BCL-2 gene expression. Resistance training and vitamin D Ca++ chitosan nanoparticle supplements seemed to reverse these changes. Conclusion: The combination of resistance training and vitamin D Ca++ chitosan nanoparticle supplements may be considered a non-pharmacological treatment for OVX-induced apoptosis.
کلیدواژه‌های انگلیسی مقاله Apoptosis, BCL-2-associated X protein, Caspase-3, Estrogen replacement therapy, Hormone replacement therapy.

نویسندگان مقاله | Mahsa Dehghan-Manshadi
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.


| Mohammad-Ali Azarbayjani
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.


| Sirvan Atashak
Department of Exercise Physiology, Mahabad Branch, Islamic Azad University, Mahabad, Iran.


| Maghsoud Peeri
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.


| Saleh Rahmati-Ahmadabad
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.



نشانی اینترنتی http://ijrm.ssu.ac.ir/browse.php?a_code=A-10-1539-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Reproductive Physiology
نوع مقاله منتشر شده Original Article
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