Journal of Reproduction and Infertility، جلد ۲۳، شماره ۳، صفحات ۱۶۰-۱۶۹

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عنوان انگلیسی Nesfatin-1, Dopamine, and NADPH levels in Infertile Women with Polycystic Ovary Syndrome: Is There a Relationship Between Their Levels and Metabolic and Hormonal Variables
چکیده انگلیسی مقاله

Background: Polycystic ovary syndrome (PCOS) is commonest endocrine disease occurring in women of reproductive age. This study conducted to clarify altered concentrations of Nesfatin-1, nicotinamide adenine dinucleotide phosphate (NADPH), and dopamine in PCOS women and controls. Also, to assess their role in PCOS pathophysiology and their correlation with measured biochemical parameters.
Methods: In this observational study, 60 PCOS patients and 24 controls included. Medical history was recorded and full examinations were done. Serum concentrations of lipid profile, fasting blood glucose (FBG), fasting insulin (FSI), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, testosterone, progesterone, estradiol, Nesfatin-1, dopamine, and NADPH were measured by ELISA kits. Values were analyzed using unpaired t-test and Pearson Chi-square test. The p<0.05 was considered statistically significant.
Results: In this study, there was significantly elevated waist hip ratio (WHR) and body mass index (BMI) in PCOS patients versus controls (p<0.0001 and p=0.014). There was significant increase in FSH, LH, prolactin, estradiol, testosterone, Nesfatin-1, and dopamine (p=0.021, p=0.015, p<0.0001, p<0.0001, p=0.006, p=0.017, p<0.0001) and decrease of NADPH (p<0.0001) in PCOS patients. There were significant positive correlations between Nesfatin-1, prolactin, and dopamine levels. Also, there was significant positive correlation between dopamine and BMI, FSI, FSH, LH, estradiol, and prolactin levels; however, significant negative correlations observed between NADPH and BMI, FSI, estradiol, and prolactin levels.
Conclusion: Elevated serum Nesfatin-1 concentrations and their association with hyperprolactinemia indicate that they have a role in PCOS pathophysiology. Moreover, elevated dopamine and decreased NADPH concentrations could play role in PCOS pathogenesis.

کلیدواژه‌های انگلیسی مقاله Dopamine, Infertility, Nesfatin-1, Nicotinamide adenine dinucleotide phosphate, Polycystic ovarian syndrome, Prolactin

نویسندگان مقاله | Enas Ahmed Hamed
Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

| Hayam Gaber Sayyed
Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

| Ahmed Mohamed Abbas
Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt

| Mohamed Maher Abdel Gaber
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt

| Hassnaa Mahmoud Abd El Aleem
Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

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