مجله علمی دانشگاه علوم پزشکی قزوین، جلد ۲۵، شماره ۳، صفحات ۰-۰

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عنوان انگلیسی Association of rs11225395 polymorphism of MMP-8 gene with recurrent pregnancy loss among Iranian women
چکیده انگلیسی مقاله It is assessment that fewer than 5% of women experience recurrent pregnancy loss (RPL). Among these, metalloproteinases are important. Different Matrix metalloproteinases (MMPs) have proteolysis function and have main role in the stable development of the fetus. In this research, the associations between single nucleotide polymorphisms (SNPs) of MMP-8 gene and RPL was studied among 130 Iranian women with a history of RPL and 130 controls.Genotyping of the MMP-8 gene was done for two polymorphisms of rs2509013 C>T and  rs11225395 G>A by using sanger sequencing. Our results showed high frequency of AA genotype (OR: 2.5 CI:(1.02-4.1) ) (P<0.01) and A allele (OR:1.95 CI:(0.95-3.1)) (P <0.001)  of rs11225395 G>A polymorphism among the RPL patients in comparison to controls. Also, these trends were maintained in the haplotype and genotype combination analyses. In conclusion, we can say MMP-8 may be involve in RPL risk and is a potential biomarker for RPL susceptibility.
کلیدواژه‌های انگلیسی مقاله Recurrent pregnancy loss (RPL), Matrix metalloproteinase (MMP), MMP-8, Polymorphism

نویسندگان مقاله | Reza Najafipour
Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.


| Zahar Rashvand
Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.


| Khadijeh Taherkhani
Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.


| Solmaz Chamanara
Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.


| Shokoh Sadat Abotorabi
Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.


| Sahar Moghbelinejad
Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.



نشانی اینترنتی http://journal.qums.ac.ir/browse.php?a_code=A-10-743-5&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Genetics
نوع مقاله منتشر شده Research
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