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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۳، صفحات ۳۷۲-۳۸۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Fabrication and evaluation of bioresorbable scaffolds for interventional cardiology application with sufficient drug release |
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| چکیده انگلیسی مقاله |
Objective(s): Bioresorbable scaffolds have been advocated as the new generation in interventional cardiology because they could provide temporary scaffolds and then disappear with resorption. Although, the available stents in clinical trials exhibited biosafety, efficacy, no death, and no apparent thrombosis, Mg-substrate degradation on drug release has not been investigated.Materials and Methods: Therefore, more research has been needed to legitimize the replacement of current stents with Mg-based stents. UV-Vis spectrophotometer, scanning electron microscope (SEM), X-ray diffraction (XRD), pH measurement, H₂ evolution, and corrosion tests determined the change in hybrid properties and drug release rate. Results: The effect of Mg degradation on drug release from poly-L-lactide (PLLA) specimen was much higher than that of the L605/PLLA sample. Hydrogen evolution caused by magnesium degradation compelled everolimus out without significant PLLA decomposition during the first 100 days, while formation of Mg(OH)2 caused the PLLA to deform and crack. Conclusion: A combined mechanism of lattice/hole diffusion-dissolution governed the release of everolimus with the activation energies of 5.409 kJ/mol and 4.936 kJ/mol for the first 24 hr and diffusion coefficients 6.06×10-10 and 3.64×10-11cm2/s for the 50th to 100th days. Prolonged suppression of hyperplasia within the smooth muscle cells by hybrid stent insertion could bring about the cessation of restenosis. |
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| کلیدواژه‌های انگلیسی مقاله |
Coronary Stent, Degradation, Diffusion, Drug Delivery, Nano-hybrid |
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| نویسندگان مقاله |
| Asghar Sadeghabadi
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Seyed Khatiboleslam Sadrnezhaad
Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
| Azadeh Asefnejad
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Nahid Hassanzadeh Nemati
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_19769.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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