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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱۲، صفحات ۱۵۶۵-۱۵۷۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
LC-MS based identification of stylosin and tschimgine from fungal endophytes associated with Ferula ovina |
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| چکیده انگلیسی مقاله |
Objective(s): Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites.Materials and Methods: The isolated endophytic fungi were fermented in potato dextrose broth (PDB) medium and their extracts were screened for the presence of the plant compounds by liquid chromatography-tandem mass spectrometry (LC-MS). Endophytes identification was performed by morphological and molecular methods. Three markers (ITS, LSU, and TEF1) were used for accurate molecular identification. Results: Forty isolates from 9 different genera of endophytic fungi were identified, of which two recently reported species of O. ferulica and Pithoascus persicus were able to produce tschimgine and stylosin. Conclusion: These fungi can be used as a substitute for the production of plant’s medicinal compounds independent of wild populations of the source plant. |
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| کلیدواژه‌های انگلیسی مقاله |
Ferula ovina, Fungal endophytes, Ochroconis ferulica, Pithoascus persicus, Stylosin, Tschimgine |
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| نویسندگان مقاله |
| Zahra Tazik
Department of Plant Protection, Faculty of Plant Production, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
| Kamran Rahnama
Department of Plant Protection, Faculty of Plant Production, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
| James White
Department of Biology, Rutgers University, New Brunswick, New Jersey, U.S.A.
| Hassan Soltanloo
Department of Biotechnology & Plant Breeding, Faculty of Plant Production, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
| Maede Hasanpour
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
| Mehrdad Iranshahi
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_16863.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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