Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۴، صفحات ۵۲۴-۵۳۰

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عنوان انگلیسی Investigating the basis for the antidepressant effects of Gleditsiae spina using an integrated metabolomic strategy
چکیده انگلیسی مقاله Objective(s): Gleditsiae spina (GS) is a natural antidepressant but its mechanisms of action remain unclear. In the present study, taxifolin (Tax) was selected to determine the role of flavonoids in the antidepressant effects of GS.Materials and Methods: Urine samples from C57BL/6 mice were analyzed based on  ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q/TOF-MS). Then, we investigated the therapeutic effects of GS and Tax in depression models in vivo. An integrated metabolomic approach was used to examine the metabolic profiles of GS/Tax groups and corticosterone model groups (Cor). Metabolic networks in response to GS/Tax treatment were established for the comparison of antidepressant activities.Results: Corticosterone exposure significantly increased serum levels of corticosterone but decreased serum levels of 5-hydroxytryptamine and sucrose consumption (p <0.01). Treatment with GS and Tax improved all measured variables compared to those of the corticosterone-exposed group (p < 0.01). The antidepressant effects of GS and Tax involved the regulation of pentose and glucuronate interconversions, arginine and proline metabolism, phenylalanine metabolism, taurine and hypotaurine metabolism, and the citrate cycle.Conclusion: These findings indicate that flavonoids form the pharmacodynamic basis of the antidepressant effects of GS. Moreover, our findings highlight that integrated metabolomics provides a powerful tool to study the mechanisms and material basis of Chinese herbs.
کلیدواژه‌های انگلیسی مقاله Biomarker, Depression, Flavonoids, Metabolomics, Metabolic profiling

نویسندگان مقاله | Tong Liu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China


| Ning Zhou
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China


| Yangang Cao
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China


| Ruihao Xu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China


| Zhen Liu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China


| Xiaoke Zheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China|The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, RP China


| Weisheng Feng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China|The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, RP China



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