Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۹، صفحات ۱۲۴۷-۱۲۵۳

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عنوان انگلیسی Irisin protects female mice with LPS-induced endometritis through the AMPK/NF-κB pathway
چکیده انگلیسی مقاله Objective(s): This research was designed to determine the role of irisin in lipopolysaccharide (LPS)-induced endometritis in female mice. Materials and Methods: Animals were randomly assigned into sham, sham + irisin, LPS, LPS + irisin (0.1, 1, 10 μg/kg), and LPS + irisin + compound C groups. Histological features and expression of AMPK, NF-κB, inflammatory mediators, and oxidative stress markers were compared among different groups. Results: The results showed that LPS resulted in obvious uterus damage, meanwhile, the inflammatory mediators (COX-2, iNOS, IL-1β, IL-6, and TNF-α), as well as NF-κB in the uterine tissue, were significantly increased and the level of adenosine monophosphate-activated protein kinase (AMPK) was reduced. Nevertheless, pretreatment with irisin reversed the phenomena caused by LPS. Interestingly, compound C (AMPK inhibitor) abolished irisin’s effects on the uterus, which suggested that irisin’s beneficial function was achieved through regulating the AMPK-NF-κB pathway. Moreover, LPS-induced alterations of oxidative factors (MnSOD, GSH, and MDA) were reversed significantly by pretreatment with irisin. This data indicated irisin’s beneficial function was also related to antioxidation besides anti-inflammation. Conclusion: Our study implies that irisin is a potential therapeutic agent for endometritis.
کلیدواژه‌های انگلیسی مقاله AMP-activated protein kinases, Endometritis, Inflammation, Irisin, Lipopolysaccharide NF-κB

نویسندگان مقاله | Xi Jiang
Zhejiang University Mingzhou Hospital, Ningbo, 315000, China|Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Ying Hu
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Yingjie Zhou
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Jin Chen
Zhejiang University Mingzhou Hospital, Ningbo, 315000, China


| Chonglu Sun
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Ziwei Chen
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Changfeng Jing
Zhejiang University Mingzhou Hospital, Ningbo, 315000, China


| Lexing Xu
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Fuhe Liu
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Wenjuan Ni
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Xuefeng Yu
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China


| Lei Chen
Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo, 315000, China



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