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Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۱۱، صفحات ۱۵۵۴-۱۵۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Sperm and testicular dysfunction during cecal ligation and puncture-induced sepsis in male rats and effects of tannic acid through reducing testicular oxidative stress and inflammation |
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| چکیده انگلیسی مقاله |
Objective(s): One of the problems caused by infectious diseases is the decrease in sperm count and motility. Tannic acid is known as an anti-oxidant and anti-inflammatory agent. In this study, Cecal Ligation and Puncture (CLP) sepsis model was induced to investigate the effect of tannic acid on oxidative stress and inflammation in testicular and sperm structure and function.Materials and Methods: Twenty-four male Wistar rats (250–300 g) were randomly divided into 3 groups of 8: 1) sham, 2) sepsis, and 3) sepsis + tannic acid (20 mg/kg at 6, 12, and 24 hr after sepsis induction). Thirty hours after induction of sepsis, testicular samples were collected to measure SOD activity and MDA, IL-6, and TNF-α levels. Another part of the testis was fixed in 10% formalin for histological examinations. Results: In the sepsis group, testicular MDA, TNF-α, and IL-6 levels increased and SOD activity decreased compared with the sham group. In addition, the percentage of motile sperm and the survival rate of sperm decreased significantly in the sepsis group. Administration of tannic acid significantly decreased inflammatory markers (TNF-α and IL-6) and MDA levels and increased SOD activity. Furthermore tannic acid significantly improved sperm parameters and increased sperm and animal survival rates.Conclusion: The results of this study showed that the reproductive system may be strongly affected by the conditions created during sepsis. Tannic acid improved reproductive dysfunction in sepsis by reducing oxidative stress and inflammation. |
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| کلیدواژه‌های انگلیسی مقاله |
Inflammation, Oxidative stress, Sepsis, Sperm, tannic acid, Testicular dysfunction |
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| نویسندگان مقاله |
| Fatemeh Pourmirzaei
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Mina Ranjbaran
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Mehri Kadkhodaee
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Farzaneh Kianian
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Keivan Lorian
Department of Reproductive Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Arash Abdi
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Mahdi Hajiaqaei
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Behjat Seifi
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_19028.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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