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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۱، صفحات ۱۲۱-۱۲۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study |
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| چکیده انگلیسی مقاله |
Objective(s): In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model.Materials and Methods: Thirty Wistar albino rats were divided into 3 groups. Group I was selected as the control group. Gentamicin was administered intraperitoneally in group II, gentamicin and CAPE in group III. Audiological assessment was performed by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) measurements before and after treatment of each group. At the end of the study all rats were decapitated, cochlea was removed and electron microscopic examination was performed. Results: In group II post-treatment DPOAE levels were found to be lower than pretreatment DPOAE levels (P< 0.05). However, in group III, there is no significant difference between pre- and post-treatment DPOAE levels (P>0.05). Except for Group I, ABR thresholds increased after the procedure and this increase was statistically significant (P< 0.0001). According to histological examination by transmission electron microscopy, CAPE has a cellular protective effect against gentamicin ototoxicity. Conclusion: CAPE may ameliorate hearing deterioration caused by gentamicin ototoxicity and protect the cochlear cells from apoptosis due to the strong antioxidant effect. |
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| کلیدواژه‌های انگلیسی مقاله |
Aminoglycoside, Anti-oxidant, caffeic acid phenethyl ester, Gentamicin, Ototoxicity |
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| نویسندگان مقاله |
| Fuat Aydemir
Department of Otorhinolaryngology, Kulu State Hospital, Konya, Turkey
| Cagatay Han Ulku
Department of torhinolaryngology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey
| Cigdem Elmas
Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey
| Cemile Merve Seymen
Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_19469.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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