Anatomical Sciences Journal، جلد ۶، شماره ۲۵، صفحات ۰-۰
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عنوان انگلیسی The Effect of Di-(2-Ethylhexyl) Phthalate (DEHP) on Mouse Daily Sperm Production and Epididymal Sperm Parameters
چکیده انگلیسی مقاله Purpose: The purpose of this study is to evaluate the effect of Di-(2-ethylhexyl) phthalate (DEHP) on testicular spermatid number per gram testis (TSN), daily sperm production (DSP), count, motility, viability, morphology, and chromatine quality of epididymal sperm. Materials and Methods: The protocol for DEHP administration was that adult male NMRI mice (the age group of 4 weeks) received 29 DEHP/100ul corn oil/kg, and vehicle group received 100ul corn oil/kg by gavage for 14 days. The control group did not receive DEHP. All the samples were assessed according to World Health Organization (WHO) criteria. Sperm morphology was assessed using papanicula staining. Sperm chromatine quality was assessed using aniline-blue staining. Results: Administration of DEHP induced significantly reduction of TSN, DSP and epididymal sperm count (p< 0.05). The percentage of motility, viability, normal morphology, and chromosomal quality were significantly low in comparison with control group (p< 0.05). Conclusion: These results demonstrated that DEHP administration has toxic effects on TSN, DSP, epididymal sperm parameter and finally on male reproductive system. 
کلیدواژه‌های انگلیسی مقاله Di-(2-ethylhexyl) phthalate, Daily sperm production, Sperm parameters, Toxic effects
نویسندگان مقاله | Zohre Zare


| Hossein Eimani


| Moslem Mohammadi


| Mahmoud Mofid


| Hossein Dashtnavard


نشانی اینترنتی http://anatomyjournal.ir/browse.php?a_code=A-10-304-250&slc_lang=fa&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Morphometry
نوع مقاله منتشر شده Original
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