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Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۴، صفحات ۴۰۷-۴۱۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Role of the potassium channels in vasorelaxant effect of asafoetida essential oil |
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| چکیده انگلیسی مقاله |
Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of Ferula asafoetida L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent. The present study was designed to determine whether potassium channels and intracellular calcium release contribute to AEO-induced vasodilation. Materials and Methods: Rats' thoracic aorta were isolated and denuded. Following induction of contraction by potassium chloride (60 mM), concentration-response curve was plotted by the cumulative addition of AEO (0.625-80 µl/l to the medium of rings. The vasodilatory effect of AEO was assessed before and after addition of phenylephrine and potassium channel blockers (including barium chloride (BC), 4-aminopyridine (4A) and glibenclamide (Gl)). Results: AEO relaxed the precontracted rings in a concentration-dependent manner (IC50=23 µl/l). All potassium channel blockers significantly attenuated the vasodilatory activity of AEO when they were added to rings medium before addition of KCl (p |
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| کلیدواژه‌های انگلیسی مقاله |
asafoetida essential oil, Potassium channels, aorta, Rats |
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| نویسندگان مقاله |
| Hassan Esmaeili
Department of heart, School of Medicine, Gorgan University of Medical Sciences, Gorgan, Iran
| Mansour Esmailidehaj
Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Somayeh Entezari Zarch
Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Hossein Azizian
Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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| نشانی اینترنتی |
http://ajp.mums.ac.ir/article_14791.html |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Research Article |
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