Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۴، صفحات ۴۰۷-۴۱۶

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عنوان انگلیسی Role of the potassium channels in vasorelaxant effect of asafoetida essential oil
چکیده انگلیسی مقاله Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of Ferula asafoetida L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent. The present study was designed to determine whether potassium channels and intracellular calcium release contribute to AEO-induced vasodilation. Materials and Methods: Rats' thoracic aorta were isolated and denuded. Following induction of contraction by potassium chloride (60 mM), concentration-response curve was plotted by the cumulative addition of AEO (0.625-80 µl/l to the medium of rings. The vasodilatory effect of AEO was assessed before and after addition of phenylephrine and potassium channel blockers (including barium chloride (BC), 4-aminopyridine (4A) and glibenclamide (Gl)). Results: AEO relaxed the precontracted rings in a concentration-dependent manner (IC50=23 µl/l). All potassium channel blockers significantly attenuated the vasodilatory activity of AEO when they were added to rings medium before addition of KCl (p
کلیدواژه‌های انگلیسی مقاله asafoetida essential oil, Potassium channels, aorta, Rats

نویسندگان مقاله | Hassan Esmaeili
Department of heart, School of Medicine, Gorgan University of Medical Sciences, Gorgan, Iran


| Mansour Esmailidehaj
Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Somayeh Entezari Zarch
Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Hossein Azizian
Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran



نشانی اینترنتی http://ajp.mums.ac.ir/article_14791.html
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نوع مقاله منتشر شده Original Research Article
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