Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۴، صفحات ۳۷۲-۳۸۳

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عنوان انگلیسی Ethanolic extract of Iris songarica rhizome attenuates methotrexate-induced liver and kidney damages in rats
چکیده انگلیسی مقاله Objective: The long-term sequelae of methotrexate (MTX) remain the major cause of concern for both patients and therapists. Therefore, new approaches to decrease MTX side effects are needed. The study was carried out to evaluate the effects of Iris songarica Schrenk (IS) rhizome extract against MTX-induced hepatic and renal injuries in rats. Materials and Methods: Forty male Wistar rats were randomly divided into five groups (n=8) including control, MTX, IS50, IS150 and IS300. Control and MTX groups were only treated orally with saline; whereas, IS50, IS150 and IS300 groups were treated with IS extract at three different doses (50, 150, and 300 mg/kg, respectively). Besides, the MTX and experimental groups were received a single dose of MTX (20 mg/kg) intraperitoneally on day 4. On the ninth day, animals were sacrificed, blood transaminases, urea and creatinine were assessed and the concentration of malondialdehyde (MDA) and the activity of super-oxide dismutase (SOD) were determined in both liver and kidney tissues. Moreover, hepatic and renal damages were evaluated histopathologically. Results: MTX by increasing oxidative stress (MDA) and decreasing antioxidant capacity (SOD) induced hepatic and renal damages as confirmed by biochemical and histological parameters analyses. However, treatment with IS caused significant improvements in hepatic and renal histological architectures and SOD activity (p
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نویسندگان مقاله | Hesam Moodi
Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran


| Mehran Hosseini
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran


| Mohammad Reza Abedini
Cellular and Molecular Research Center, Department of Pharmacology, Birjand University of Medical Sciences, Birjand, Iran


| Mahsa Hassanzadeh-Taheri
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran


| Mohammadmehdi Hassanzadeh-Taheri
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran



نشانی اینترنتی http://ajp.mums.ac.ir/article_14084.html
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