| چکیده انگلیسی مقاله |
Background:One of the most common side effects of cyclophosphamide (CP) is oligo-spermatozoa, azoospermia and elimination of spermatogenic cycles. This study was done to find the efficacy of simultaneous consumption of garlic (Allium sativum L.) and orchid (Orchismaculata L.) hydroalcoholic extracts on spermatogenesis and sex hormones in rats treated with CP. Methods:Forty-two male rats were divided into the six groups: control, sham, CP (5 mg/kg), garlic (10 mg/kg) + CP, orchid (40 mg/kg) + CP, garlic+ orchid + CP. All of the agents were administered through oral gavage for 28 days. Results: The number of sperms increased in garlic+ CP and orchid+ CP groups. The percentage of sperm forward motility increased in groups receiving garlic, orchid, and garlic +orchid compared with the group that received only CP. Antioxidant total capacity and testosterone level showed significant increases in garlic+ orchid, garlic and orchid groups respectively compared with the group that received only CP (P< 0.05). Also, the tissue and serum malondialdehyde levels reduced in the group received garlic +orchid compared with the group that received only CP. Conclusion:Garlic and orchid could increase the number and the motility of sperms, index of sertoli cell, antioxidant capacity and serum testosterone level. |
| نویسندگان مقاله |
Firouze Sadeghzadeh |
Traditional and Complementary Medicine Research Center, Arak University of Medical University, Arak, Iran
Azizieh Sadeghzadeh |
Traditional and Complementary Medicine Research Center, Arak University of Medical University, Arak, Iran
Saeed Changizi-Ashtiyani |
Professor, Department of Physiology, School of Paramedical Sciences, Arak University of Medical Sciences, Arak, Iran
Abass Alimoradian |
Traditional and Complementary Medicine Research Center, Arak University of Medical University, Arak, Iran
Mehry Mashayekhei |
Assistant Professor, Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran
Ali Zarei |
Assistant Professor, Department of Physiology, Shiraz University of Medical University, Shiraz, Iran
Farideh Jalali-Mashayekhi |
Assistant Professor, Traditional and Complementary Medicine Research Center, Arak University of Medical University, Arak, Iran
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