Journal of Kerman University of Medical Sciences، جلد ۲۷، شماره ۲، صفحات ۱۸۳-۱۸۹

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عنوان انگلیسی Immunohistochemical Eexpression of Endothelin A Receptor in Dysplastic Oral Mucosa
چکیده انگلیسی مقاله Background: Recent researches have provided evidences of the importance of endothelin axis in carcinogenesis. According to our knowledge, no data exists about endothelin A receptor (ETA) expression in dysplastic oral mucosa (DOM). Therefore, the aim of the present study was to evaluate immunohistochemical expression of ETA in DOM. Methods:In this cross-sectional study, paraffin-embedded tissue blocks of 20 cases of DOM and 20 cases of normal oral mucosa (NOM) were studied. Three-micron sections were prepared from tissue blocks and stained with ETA antibody using immunohistochemistry. Percentage of stained cells and staining intensity were compared between DOM and NOM groups and also between different grades of DOM using Mann-Whitney, Chi-Square and Kruskal-Wallis statistical tests. Results:In DOM group, 11 cases were stained positive for ETA and in NOM group 17 cases were not stained. Comparison of percentage of stained cells and staining intensity for ETA revealed significant difference between DOM and NOM groups (P=0.01 and 0.02, respectively). There were significant differences among different grades of DOM with respect to the percentage of stained cells (P=0.001) and staining intensity (P=0.02), so that higher grades showed greater expression for ETA. Conclusion:Our results supported ETA receptor role in the initiation of carcinogenesis process in oral cavity.
کلیدواژه‌های انگلیسی مقاله Dysplasia, Normal mucosa, Endothelin A receptor

نویسندگان مقاله Taymaz Shirali |
Babol University of Medical Sciences, Babol, Iran

Hamid Abbaszadeh |
Associate Professor, Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran

Forough Foroughi |
Assistant Professor, Pathology Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hemmat Gholinia |
Institute of Health, Babol University of Medical Sciences, Babol, Iran

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