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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۷، صفحات ۸۵۸-۸۶۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Involvement of the 5-HT1A receptor of the cuneiform nucleus in the regulation of cardiovascular responses during normal and hemorrhagic conditions |
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| چکیده انگلیسی مقاله |
Objective(s): The 5-hydroxytryptamine1A (5-HT1A) receptor is one of the serotonin receptors in the brain, which regulates cardiovascular responses, especially in hemorrhage. Presence of this receptor in the cuneiform nucleus (CnF) has been shown. The present study evaluates the cardiovascular effect of this receptor of the CnF in normal and hypotensive hemorrhagic rats.Materials and Methods: Agonist (8-OH-DPAT) and antagonist (WAY-100635) of 5-HT1A microinjected into the CnF in basal and hemorrhagic conditions and cardiovascular responses were evaluated. Hemorrhage induced by blood withdrawal from the femoral artery and 2 min after that drugs microinjected. Time course and peak changes (∆) of the mean arterial pressure (MAP), systolic blood pressure (SBP) and heart rate (∆HR) were obtained and compared to the control and hemorrhage groups.Results: In basal condition, 8-OH-DPAT significantly decreased ∆SBP, ∆MAP and ∆HR compared to the control (P |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Reza Mohebbati
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Mahmoud Hosseini
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Majid Khazaei
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Abolfazl Khajavirad
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Mohammad Naser Shafei
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_15504.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2416898.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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