Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۶، صفحات ۸۰۰-۸۰۹
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عنوان انگلیسی Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia
چکیده انگلیسی مقاله Objective(s): The current study aimed to investigate the relationship of genetic polymorphism and plasma methotrexate (MTX) levels, toxicity experience and event free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL). Materials and Methods: The study included 74 ALL patients. Polymerase chain reaction and genotyping of methylene tetrahydrofolate reductase (MTHFR) rs1801133, MTHFR rs1801131, ATP-binding cassette superfamily B1 (ABCB1) rs1045642, ATP-binding cassette superfamily G2 (ABCG2) rs2231142 and solute carrier 19A1 (SLC19A1) rs1051266 genetic variations were performed. The plasma MTX levels were investigated at 48 hr after the first dose of MTX infusion.Results: MTHFR rs1801133 TT genotype, ABCBa1 rs1045642 CT genotype and ABCG2 rs2231142 CA genotype revealed a statistically significant association with the MTX plasma levels (P
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نویسندگان مقاله | Mohammad Ali Esmaili
Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran


| Ahmad Kazemi
Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Faranoush
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran|Mahak Hematology Oncology Research Center (MAHAK-HORC), Mahak Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Hakan Mellstedt
Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm 17176, Sweden


| Farhad Zaker
Cellular and Molecular Research Center, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran


| Majid safa
Cellular and Molecular Research Center, Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran


| Narjes Mehrvar
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Reza Rezvany
Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran|Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran|Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm 17176, Sweden
نشانی اینترنتی http://ijbms.mums.ac.ir/article_15480.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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