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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۵، صفحات ۶۲۳-۶۲۸
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عنوان فارسی |
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چکیده فارسی مقاله |
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کلیدواژههای فارسی مقاله |
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عنوان انگلیسی |
Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice |
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چکیده انگلیسی مقاله |
Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mice were treated with IL-36Ra DNA or pcDNA3.1 control plasmid using a hydrodynamic gene delivery approach. Results: Our data reveal that treatment with IL-36Ra decreased liver inflammation and serum level of aminotransferases. Furthermore, IL-36Ra reduced ConA-induced pro-inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and IL-17A) production when compared to control plasmid. Conclusion: Our results demonstrated that IL-36Ra is a critical protector against ConA-induced liver injury. |
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کلیدواژههای انگلیسی مقاله |
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نویسندگان مقاله |
| Xiao Peng Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
| Xiuhe Pan Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
| Jun Tan Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
| Yan Li Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
| Mingcai Li Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
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نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_15195.html |
فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2324021.pdf |
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زبان مقاله منتشر شده |
en |
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نوع مقاله منتشر شده |
Original Article |
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