Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۳، صفحات ۲۹۸-۳۰۲

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عنوان انگلیسی Dopaminergic D1 receptors in nucleus basalis modulate recovery from propofol anesthesia in rats
چکیده انگلیسی مقاله Objective(s): Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA).Materials and Methods: Thirty-nine SD rats were randomly split into D1 receptor agonist (chloro-APB), D1 receptor antagonist (SCH23390), and saline groups after preparing NB microinjection model. We observed the effect of NB microinjection of SCH23390, chloro-APB, or saline on the period of induction and recovery time of propofol anesthesia and recorded the changes of electroencephalogram (EEG) simultaneously.Results: NB microinjection of chloro-APB accelerated the recovery from propofol anesthesia (P0.05); NB microinjection of SCH23390 produced the opposite effects. NB microinjection of saline did not influence the induction or recovery of propofol anesthesia (P>0.05). NB injection of chloro-APB decreased the ratio of δ power and increasedαand β ratios in prefrontal cortex EEG (P
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نویسندگان مقاله | Yuran Zhou
Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Dalian road 149, Zunyi 563000, Guizhou, China


| Yuran Zhou
Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Dalian road 149, Zunyi 563000, Guizhou, China


| Bao Fu
Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Dalian road 149, Zunyi 563000, Guizhou, China



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زبان مقاله منتشر شده en
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