Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۲، صفحات ۲۲۴-۲۳۵

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عنوان انگلیسی Pharmacological and computational evaluation of Sapodilla and its constituents for therapeutic potential in hyperactive gastrointestinal disorders
چکیده انگلیسی مقاله Objective(s): This study was designed to investigate various gastrointestinal effects of Manilkara zapota (Sapodilla), exploring its anti-diarrheal, anti-secretary, anti-spasmodic, anti-ulcer and anti-motility potential.Materials and Methods: Antidiarrheal and anti-secretary activities were investigated using castor oil induced diarrhea and castor oil induced fluid accumulation. Isolated rabbit jejunum tissues (antispasmodic) were employed for in vitro experiments. Antiulcer, antimotility and molecular docking were performed using ethanol-HCl induced ulcer assay, charcoal meal transit time and Auto Doc Vina.Results: Mz.Cr exhibited protection against castor oil-induced diarrhea (P
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نویسندگان مقاله | Muhammad Bilal Riaz
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad


| Arif-ullah Khan
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad


| Neelam Gul Qazi
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad



نشانی اینترنتی http://ijbms.mums.ac.ir/article_14287.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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