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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱، صفحات ۳۶-۴۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS |
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| چکیده انگلیسی مقاله |
Objective(s): Zinc is an effective factor in the reproductive system. Insulin resistance (IR) is known as an important disorder in patients with polycystic ovary syndrome (PCOS). Mammalian target of rapamycin (mTOR), which controls key cell activities, in particular, is activated in disorders such as PCOS. The present study was conducted to observe the therapeutic effects of organic zinc on IR, mTOR gene expression, and pathogenesis of PCOS in a rat model induced-PCOS. Materials and Methods: Experimental treatments were performed on control and treated groups, consisting of healthy controls (Control, water, and standard feed intake and daily injection of sesame oil alone), Polycystic control (PCO, injection of 4 mg/kg estradiol valerate (EV) for four weeks). Treated groups (PCO-ZM 25, PCO-ZM 75, and PCO-ZM 175) after 4 weeks of receiving EV, were daily given three levels of 25, 75, and 175 mg zinc methionine/kg BW for 15 days, respectively.Results: Injection of EV dramatically increased body and ovarian weights, levels of LH, testosterone, estradiol, triglyceride, fasting insulin, fasting glucose, HOMA-IR, IGF-1, gene expression of mTOR, and number of cysts (P |
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| نویسندگان مقاله |
| Faeze Fazel Torshizi
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Mohammad Chamani
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Hamid Reza Khodaei
Department of Animal Sciences, Islamic Azad University, Golpayegan Branch, Isfahan, Iran
| Ali Asghar Sadeghi
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Seyed Hossein Hejazi
Skin Disease and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
| Reza Majidzadeh Heravi
Department of Animal Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_14182.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2060536.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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