Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۱۰، صفحات ۱۲۰۳-۱۲۱۰

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عنوان انگلیسی The protective effect of Liza klunzingeri protein hydrolysate on carbon tetrachloride-induced oxidative stress and toxicity in male rats
چکیده انگلیسی مقاله Objective(s): Today, consumers are looking for food products providing health benefits in addition to meeting the basic nutritional needs of the body. This study aimed to evaluate the antioxidant and cytotoxic effects of Liza klunzingeri protein hydrolysate both in vivo and in vitro.Materials and Methods: Fish protein hydrolysate (FPH) was prepared using enzymatic hydrolysis with papain. In vitro antioxidant activity was assessed using five different antioxidant assays. The cytotoxic effect on 4T1 cell line was evaluated using the MTT assay. The distribution of the molecular weight of FPH was measured using HPLC. In the in vivo study, CCl4-exposed Wistar rats were orally treated with FPH (150, 300, and 600 mg/kg) or gallic acid (50 mg/kg) for 28 consecutive days.Results: Enzymatic hydrolysis gave hydrolysate rich in low molecular weight peptides (Conclusion: L. klunzingeri protein hydrolysate can be considered as a functional food to alleviate oxidative stress.
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نویسندگان مقاله | Sana Rabiei
Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, Noor, Iran


| Masoud Rezaie
Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, Noor, Iran


| Zahra Abasian
Medical Plants Research Center, Basic Health Sciences Institutes, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Mohammad Khezri
Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, Noor, Iran


| Mehdi Nikoo
Department of Pathobiology and Quality Control, Artemia and Aquaculture Research Institute, Urmia University, Urmia, Iran


| Mahmoud Rafieian-kopaei
Medical Plants Research Center, Basic Health Sciences Institutes, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Maryam Anjomshoaa
Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran



نشانی اینترنتی http://ijbms.mums.ac.ir/article_13793.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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