| چکیده انگلیسی مقاله |
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups. Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways. Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms. |
| نویسندگان مقاله |
| Kambiz Gilany
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran|Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
| Ashraf Mohamadkhani
Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Saeed Chashmniam
Department of Chemistry, Sharif University of Technology, Tehran, Iran
| Parisa Shahnazari
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
| Mehdi Amini
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
| Babak Arjmand
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
| Reza Malekzadeh
Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Bibi Fatemeh Nobakht Motlagh Ghoochani
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran|Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
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