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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۳، صفحات ۲۰۲-۲۰۸
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عنوان فارسی |
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چکیده فارسی مقاله |
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عنوان انگلیسی |
The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) |
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چکیده انگلیسی مقاله |
Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the virus and the immune response plays an important role in HTLV-I-associated diseases. Although the role of the immune response in HTLV-I pathogenesis is not fully understood, however it seems that the efficacy of the immune response which is involved in controlling or limiting of viral persistence determines the outcome of HTLV-I-associated diseases. Here we discuss the role of innate and adaptive immune response and also the risk factors contribute to the observed differences between HAM/TSP patients and asymptomatic HTLV-I carriers. |
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کلیدواژههای انگلیسی مقاله |
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نویسندگان مقاله |
| Houshang Rafatpanah Inflammation and Inflammatory Diseases Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
| Reza Farid Hosseini2 Allergy Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
| Seyed Hassan Pourseyed Inflammation and Inflammatory Diseases Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
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نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_732.html |
فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1549063.pdf |
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زبان مقاله منتشر شده |
en |
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نوع مقاله منتشر شده |
Review Article |
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