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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۷، صفحات ۷۵۲-۷۵۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway |
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| چکیده انگلیسی مقاله |
Objective(s): Cognitive deficit is a common problem in epilepsy. A major concern emergent from the use of antiepileptic drugs includes their side effects on learning and memory. Herbal medicine is considered a complementary and alternative therapy in epilepsy. Apigenin is a safe flavone with antioxidant properties. However, there is little information about the beneficial effect of apigenin on cognition in epilepsy. Materials and Methods: For evaluating the anticonvulsant effect of apigenin in the kainite temporal epilepsy model, apigenin was orally administered at 50 mg/kg for six days. Reference and working memory were examined via the Morris water maze and Y-maze task spontaneously. Results: Results showed that apigenin had significant anticonvulsant activity (P< 0.01) and restored the memory-deficit induced by kainic acid (P< 0.05). Furthermore, apigenin significantly increased the number of living neurons in the hilus (P< 0.001). Immunohistochemical analysis showed that apigenin reduced the release of cytochrome c (P< 0.01), suggesting an inhibitory role in the intrinsic apoptotic pathway. Conclusion: These results suggest that apigenin restores memory impairment via anticonvulsant and neuroprotective activity. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Paria Hashemi
Department of Physiology, School of Medicine and Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran
| Javad Fahanik Babaei
Physiology Research Centre, Iran University of Medical Sciences, Tehran, Iran
| Somayeh Vazifehkhah
Department of Physiology, School of Medicine and Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran
| Farnaz Nikbakht
Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_13163.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1544949.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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