Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۵، صفحات ۵۴۷-۵۵۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Physicochemical and pharmacological evaluation of carvedilol-eudragit® RS100 electrosprayed nanostructures
چکیده انگلیسی مقاله Objective(s): This study was carried out to boost the pharmacologic influence of carvedilol (CAR) (as a poorly water-soluble drug) by developing CAR-eudragit® RS100 (Eud) nanofibers and nanobeads benefiting an electrospraying approach. Materials and Methods: CAR-Eud nanoformulations with varying ratios (1:5 and 1:10) at total solution concentrations of 10 %, 15 % and 20 % w/v were formulated. Results: The solution concentration remarkably impressed the size and morphology of the samples; in which, the nanobeads (mean diameter of 135.83 nm) were formed at low solution concentrations and high concentrations led to nanofibers (mean diameter of 193.45 nm) formation. DSC thermographs and PXRD patterns along with FTIR spectrum precisely showed CAR amorphization and no probable chemical interactions between CAR and Eud in the electrosprayed nanosystems. The in vitro release considerations demonstrated that the nanoformulations with the drug: polymer ratios of 1:10 and 1:5 depict rapid dissolution rate compared to the physical mixtures (PMs) and the pure drug. The in vivo studies in Wistar male rats suggested that the electrosprayed nanoformulation (1:10; 20 %) reduced the isoproterenol (ISO) induced elevation of heart rate, necrosis and accumulation of neutrophils in the heart tissue more efficient than the pure drug and PM. Conclusion: Our finding illustrated that the electrospraying as a profitable one-step procedure could be productively benefited to improve the physicochemical features and pharmacologic influences of CAR.
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نویسندگان مقاله | Sevil Selselehjonban
Research Center for Pharmaceutical Nanotechnology, Biomedicines Institute, Tabriz University of Medical Sciences, Tabriz, Iran|Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran


| Alireza Garjani
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


| Karim Osouli-Bostanabad
Research Center for Pharmaceutical Nanotechnology, Biomedicines Institute, Tabriz University of Medical Sciences, Tabriz, Iran|Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran


| Ali Tanhaei
Research Center for Pharmaceutical Nanotechnology, Biomedicines Institute, Tabriz University of Medical Sciences, Tabriz, Iran


| Shahram Emami
Research Center for Pharmaceutical Nanotechnology, Biomedicines Institute, Tabriz University of Medical Sciences, Tabriz, Iran


| Khosro Adibkia
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


| Mohammad Barzegar-Jalali
Research Center for Pharmaceutical Nanotechnology, Biomedicines Institute, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12579.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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