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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۳، صفحات ۲۵۵-۲۶۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
The effect of alpha linolenic acid on tracheal responsiveness, lung inflammation and immune markers in sensitized rats |
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| چکیده انگلیسی مقاله |
Objective(s): The effects of alpha linolenic acid (ALA) on tracheal responsiveness (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), interleukin 4 (IL-4), interferon gamma (INF-γ) level and INF-γ/IL4 ratio in bronchoalveolar lavage fluid (BALF) of sensitized rats were examined.Materials and Methods: TR to methacholine and ovalbumin (OA), BALF levels of TP, PLA2 and IgE as well as IL-4, INF-γ and INF-γ/IL4 ratio were measured in control group (non-sensitized, group C), sensitized rats to OA (group S), S groups treated with two concentrations of ALA and dexamethasone group. Results: TR to methacholine and OA, BALF levels of TP, PLA2, IgE and IL-4 were significantly increased but BALF level of INF-γ and INF-γ/IL4 ratio decreased in group S compared to group C (PConclusion: Results showed an immune modulatory effect of the ALA that increased INF-γ, INF-γ/IL4 ratio (as an index of Th1/Th2) and decreased IL-4 in sensitized rats. ALA also showed preventive effect on inflammatory markers and tracheal responsiveness in sensitized animals comparable to the effect of dexamethasone. |
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| نویسندگان مقاله |
| Mahsa Kaveh
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Naeima Eftekhar
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Iran
| Mohammad Hossein Boskabady
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_12205.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1224104.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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