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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۲، صفحات ۱۱۲-۱۱۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis |
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| چکیده انگلیسی مقاله |
Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment and implementation of inclusion/exclusion criteria. This meta-analysis was performed using Review Manager 5.2 software. The odds ratios (ORs) with corresponding 95% confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger's regression tests were used to assess the publication bias. Results: A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE polymorphisms and depression. APOE ε4 allele was significantly associated with depression (allele: OR=1.36, 95%CI=1.11-1.66, P=0.003; dominant: OR=1.34, 95%CI=1.06-1.68, P=0.001; recessive: OR= 1.11, 95%CI =0.45-2.76, P=0.82). HAMD scores were higher in depression patients with-APOE ε4 genotype than who without-APOE ε4 genotype (OR=0.96, 95%CI=0.16-1.76, P=0.02). Conclusion: APOE ε4 allele increased the depression risk; depressive patients carrying APOE ε4 allele had more severe depressive symptoms. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Wei-wei Wang
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China
| Xiao-lei Liu
The First Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China
| Ye Ruan
Mental Health Center of Kunming Medical University, Kunming City, Yunnan Province, PR China
| Lin Wang
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China
| Tianhao Bao
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China|Mental Health Center of Kunming Medical University, Kunming City, Yunnan Province, PR China
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_12084.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1142606.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Review Article |
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