|
|
Journal of Kerman University of Medical Sciences، جلد ۲۵، شماره ۳، صفحات ۲۴۳-۲۵۴
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Destruction of Recombinant Tissue Plasminogen Activator (rtPA) -Loaded Echogenic Liposomes under Dual Frequency Sonication |
|
| چکیده انگلیسی مقاله |
Background:Echogenic liposomes (ELIPs) encapsulate drugs and gas bubbles within lipid vesicles. The destruction of ELIPs in response to MHz and kHz ultrasound waves has been studied previously. Applying ultrasound above a certain threshold causes encapsulated gas bubbles destruct rapidly by fragmentation or more slowly by acoustically driven diffusion. This study compares the destruction of recombinant tissue plasminogen activator (rtPA) -loaded echogenic liposomes using three frequency protocols: 130 kHz, 1 MHz and dual (130 kHz + 1 MHz). Method:In gel phantom, ELIPs were imaged by diagnostic ultrasound system and simultaneously destructive ultrasonic fields were applied at different intensities in each protocol. Images were analyzed. Results:According to the results, 80% decline in MGV (mean of gray value) relative to initial MGV was associated with ELIPs fragmentation. At 130 kHz, results showed an 80% decline in MGV and fragmentation happened at all applied ultrasound intensities (0.01 W/cm2 as fragmentation threshold). In MHz and dual protocols, on average, less than 50% decline in MGV was observed which indicated an acoustically driven diffusion. Conclusion:Our study shows that kHz protocol fragments ELIPs more effectively than other two protocols. For better results, dual frequency protocols need optimized combination of frequencies and phases. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
Mosayyeb Mobasheri |
Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Manijeh Mokhtari |
Professor, Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Tayebeh Toliyat |
Associate Professor, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Masoud Mehrpour |
Associate Professor, Department of Neurology, Firoozgar Hospital, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran
|
|
| نشانی اینترنتی |
http://jkmu.kmu.ac.ir/article_76884_b6ba82f16b422065f0ddaa2982d1b085.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-1007420.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|