Iranian Journal of Pharmaceutical Sciences، جلد ۱، شماره ۱، صفحات ۲۷-۳۱
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عنوان انگلیسی Effects of 2-Alkylamino-Substituted Dihydropyridines on Rabbit Jejunum
چکیده انگلیسی مقاله In order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethy- lamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicar- boxylates (6a-f) were synthesized. The synthesis was started from dialkyl 1,4- dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicar- boxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the synthesized compounds. Some of the compounds (6c-e) inhibited the spontaneous contractile activity of jejunum, dose-dependently and completely, while high-K+ contracted tissues were relaxed partially.
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نویسندگان مقاله فرزین هادی زاده |
department of medicinal chemistry, faculty of pharmacy, mashhad university of medical sciences, p.o.box 91775-1365 , mashhad, iran biotechnology and pharmaceutical sciences research center, postal code 9196773117, bu-ali square, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

بی بی فاطمه انارکی فیروز | bibi fatemeh anaraki firooz
biotechnology and pharmaceutical sciences research center, postal code 9196773117, bu-ali square, mashhad, iran

سید intasar حسین taqvi | syed intasar husain taqvi
department of pharmacology, jinnah medical and dental college, karachi, pakistan

نشانی اینترنتی http://www.ijps.ir/article_1851_078bde32b5a7ac5640a058e9fe329470.pdf
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