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Iranian Journal of Pharmaceutical Sciences، جلد ۹، شماره ۲، صفحات ۸۷-۱۰۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Lornoxicam Alone and with Selegiline Improves the Neuroprotective Effect and Cognition in Scopolamine Induced Neurodegeneration and Cognitive Impairment in Rats |
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| چکیده انگلیسی مقاله |
Alzheimer is a progressive neurodegenerative disorder in which Oxidative stress plays a major role. The present study was designed to investigate Neuroprotective effect of Lornoxicam, Selegiline and co-administration of both drugs in Scopolamine induced cognitive impairment and neurodegeneration. Scopolamine (1.4mg/kg) was administered intraperitoniallyin male Wistar rats. Rectangular maze performance test was used to assess the memory performance test. Various biochemical parameters such as Catalase, 1, 1-diphenyl-2- picrylhydrazine (DPPH), Thiobarbituric acid reactive substances(TBARS), reduced glutathione(GSH) and acetylcholine esterase (AchE) were also assessed. IntraperitonialScopolamine results marked memory impairment and oxidative damage. Sub-acute treatment with Lornoxicam (1.3mg/kg, p.o) and Selegiline (0.49mg/kg, p.o) and co-administration of these two drugs for 8 days significantly attenuated scopolamine induced oxidative damage and neurodegeneration. Besides, Lornoxicam, Selegiline and co-administration of both significantly reversed Scopolamine administered increase in acetylcholine esterase activity. Present study indicates protective effect of Lornoxicam, Selegiline and co-administration of both drugs against Scopolamine induced cognitive impairment and oxidative damage. The memory enhancing capacity of the drugs was very significant when compared with disease control (P |
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| نویسندگان مقاله |
sainath reddy k | reddy k
department of pharmacology, vaagdevi college of pharmacy, warangal, india.
kaleem علی اکبر | a k
department of pharmacology, vaagdevi college of pharmacy, warangal, india.
sharvana bhava b s | bhava b s
department of pharmacology, vaagdevi college of pharmacy, warangal, india.
satish p |
department of pharmacology, vaagdevi college of pharmacy, warangal, india.
aravind p |
department of pharmacology, vaagdevi college of pharmacy, warangal, india.
venkateshwarlu e |
department of pharmacology, vaagdevi college of pharmacy, warangal, india.
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| نشانی اینترنتی |
http://www.ijps.ir/article_5721_1dbc74f2b18c0391ca409ac6260d5840.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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