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Iranian Journal of Pharmaceutical Sciences، جلد ۹، شماره ۴، صفحات ۵۱-۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Synthesis and Biological Activity of Certain Mannich Bases Derivatives from 1, 2, 4-Triazoles |
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| چکیده انگلیسی مقاله |
Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Triazole Quinazolines were synthesized from 5-Marcapto-s-Trizole by reacting with the Quinazoline benzoic acid or acid chlorides. In the second scheme, the synthesis of Quinazolyl Triazolo Thiadiazole Derivatives were prepared by the reaction of Quinazoline benzoic acid and 5-Marcapto-s –Triazoles in POCl3.All the newly synthesized compound structures were elucidated using various spectral techniques viz. IR, 1HNMR and screened for in vitro antibacterial and anti fungal activities. Anti bacterial activity was carried out against organisms Bacillus pumilus, Bacillus subtilis, Staphylococcus aureus, and Escherichia coli as well as anti fungal activity were carried out against A.Nigier and C.Albicans. The results substantiated that the synthesized compounds were effective against bacteria, fungi. |
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| نویسندگان مقاله |
subhas sahoo |
department of pharmaceutical chemistry, pulla reddy institute of pharmacy, hyderabad, india
pranesh patwari k | patwari k
department of pharmaceutical chemistry, saraswathi college of ph. sciences, hyderabad, india
mahendra کومار c b | kumar c b
department of pharmaceutical chemistry, st mary college of pharmacy, secunderabad, india
c maliikarjuna setty | c maliikarjuna
department of pharmaceutics, oxford college of pharmacy. banglaore, india.
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| نشانی اینترنتی |
http://www.ijps.ir/article_10248_b02d56dcd5b30e0eabfb136e9369ef80.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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