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Iranian Journal of Pharmaceutical Sciences، جلد ۱۲، شماره ۱، صفحات ۵۹-۶۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Anti- Angiogenic Activity of Vitex agnus castus Methanol Extract in vivo Study |
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| چکیده انگلیسی مقاله |
This study aimed to investigate the anti-angiogenic activity of Vitex agnus castus methanol extract in vivo. Eggs were incubated for three days, small whole made on the fine pinpoint, next day the egg’s sac penetrated and a small frame was made in the shell. The window was resealed and eggs were returned to the incubator until day 10 of chick embryo development, 20 µl of 500mg/ml of the methanol extract transferred to the Chick Embryo Chorioallantoic Membrane (CAM), and eggs incubated for 72 hours (n = 6); The zone of inhibition calculated as mean of inhibition area in millimetre (mm) ±Standard deviation (SD). Functional groups of the chemicals component inside the extract has been identified by Fourier transform infrared spectroscopy FT-IR and High performance liquid chromatography HPLC used to identify the most likely causative agent. The results showed that the zones of inhibition area more than 10 mm. FT-IR showed that some of the identified functional group may relate to flavonoids. Casticin has identified in methanol extract. Because of the above results the mechanism of anti-angiogenic activity for the methanol extract of the Vitex agnus castus may relate to the Casticin which has the ability to block the VEGF-receptor, thereby inhibiting the angiogenesis process. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
hayder b صاحب | hayder b
deputy dean college of pharmacy al-nahrain university baghdad iraq
ادیب a alzubaidy | adeeb a
dean college of pharmacy alnahrain university
ghaith a جسیم | ghaith a
lecturer college of pharmacy al-mustanseriya university
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| نشانی اینترنتی |
http://www.ijps.ir/article_19006_9bbb9ae52ad6fbc76c82d97af2d8d57b.pdf |
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| زبان مقاله منتشر شده |
en |
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