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Basic and Clinical Neuroscience، جلد ۷، شماره ۳، صفحات ۲۴۱-۲۴۸
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عنوان انگلیسی Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex
چکیده انگلیسی مقاله Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified. However, changes in the functions of μ-opioid and N-Methyl-D-aspartate (NMDA) receptors have been proposed in morphine tolerance. We examined changes in gene expression of the NMDA receptor subunit 1 (NR1) at mRNA levels in rat striatum and prefrontal cortex (PFC) after induction of morphine tolerance. Methods: Morphine (10 mg/kg, IP) was injected in male Wistar rats for 7 consecutive days (intervention group), but control rats received just normal saline (1 mL/kg, IP). We used a hotplate test of analgesia to assess induction of tolerance to analgesic effects of morphine on days 1 and 8 of injections. Later, two groups of rats were sacrificed one day after 7 days of injections, their whole brains removed, and the striatum and PFC immediately dissected. Then, the NR1 gene expression was examined with a semi-quantitative RT-PCR method. Results: The results showed that long-term morphine a administration induces tolerance to analgesic effect of the opioid, as revealed by a significant decrease in morphine-induced analgesia on day 8 compared to day 1 of the injections (P< 0.001). The results also showed that the NR1 gene expression at mRNA level in rats tolerant to morphine was significantly increased in the striatum (P< 0.01) but decreased in the PFC (P< 0.001). Conclusion: Therefore, changes in the NR1 gene expression in rat striatum and PFC have a region-specific association with morphine-induced analgesic tolerance.
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نویسندگان مقاله شمس الدین احمدی | shamseddin ahmadi
department of biological science and biotechnology, faculty of science, university of kurdistan, sanandaj, iran.


فاطمه رفیعی نیا | fatemeh rafieenia
department of biological science and biotechnology, faculty of science, university of kurdistan, sanandaj, iran


جلال رستم زاده | jalal rostamzadeh
department of biological science and biotechnology, faculty of science, university of kurdistan, sanandaj, iran
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-373-3&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and molecular Neuroscience
نوع مقاله منتشر شده Original
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