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Middle East Journal of Digestive Diseases، جلد ۱۰، شماره ۲، صفحات ۹۶-۱۰۴
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عنوان انگلیسی The Association between Angiotensin II Type 1 Receptor Gene A1166C Polymorphism and Non-alcoholic Fatty Liver Disease and Its Severity
چکیده انگلیسی مقاله BACKGROUND Genetic predisposition may have important role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Angiotensin II type I receptor (AGTR1) has been known to involve in the process of liver steatosis and fibrosis. This study aimed to investigate the association between AGTR1 A1166C polymorphism and NAFLD. METHODS A cross-sectional study was conducted during May 2014-May 2015 among healthy adults referring to our radiology clinic for abdominal sonography. AGTR1 A1166C polymorphism was evaluated in subjects with NAFLD and healthy individuals using allelic discrimination method. RESULTS 58 subjects with NAFLD were compared with 88 healthy individuals without NAFLD. The frequency of AA and CC genotypes of AGTR1 was significantly higher in patients with NAFLD compared with controls ( p =0.029 and 0.042, respectively). C allele was more detected in subjects with NAFLD compared with the healthy controls (OR: 2.1; 95% CI: 1.23-3.61, p =0.006). CC genotype (OR: 10.62; 95% CI: 1.05-106.57, p =0.045) and C allele (OR: 6.81; 95% CI: 1.42- 32.48, p =0.016) were also predictors of severe fatty liver disease in our study population. CONCLUSION Our results provide the first evidence that AGTR1 gene A1166C polymorphism not only is associated with NAFLD and but also may predict its severity.
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نویسندگان مقاله | Ahad Eshraghian


| Shahrokh Iravani


| Pedram Azimzadeh


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/1842
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/332/article-332-926852.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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