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Gastroenterology and Hepatology From Bed to Bench، جلد ۹، شماره ۲، صفحات ۲۰۱۶-۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Lack of BRAF-V600E mutation in stage I and II of colorectal cancer |
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| چکیده انگلیسی مقاله |
Aim : We aimed to explore the frequency of BRAF V600E mutation in Iranian patients with colorectal cancer (CRC) as well as its association with clinic pathological characteristic of patients. Background : CRC is the third leading cause of cancer related death. There is a growing body of data showing the association of BRAF V600E mutation with malignant transformation and clinical outcome of different tumors, including CRC. These findings suggest that BRAF V600E mutation can be used as diagnostic and/or prognostic biomarker for management of cancer patients. Patients and methods : A total of 85 patients with sporadic tumor were recruited. Braf V600E mutation was investigated using sequencing of extracted DNAs from formalin-fixed paraffin-embedded (FFPE) tumor tissues. Electropherograms were analyzed using Laser-gene 6 software. Results : More than 95% of patients were in stage I and II and none of them were in stage IV. Patients were mostly below 55 years old and tumors were dominantly located in the distal colon. Of note, no BRAF V600E mutations were detected in our population. Conclusion : Our results showed no V600E mutation in the BRAF gene in stage I and II of CRC patients. Further studies in multi-center settings are warranted to examine the prognostic and/or predictive value of this marker in different stages of colorectal cancer patients. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
دکتر مهسا مولایی | mahsa molaei
royai کیشانی فراهانی | royai kishani farahan
مینا maftouh | mina maftouh
محمد یعقوب طالقانی | mohammad yaghoob taleghani
مهسا وحدتی نیا | mahsa vahdatinia
خاتمی | fatemeh khatami
احسان احسان مجرد | ehsan nazemalhosseini mojarad
حمید اسدزاده aghdae | hamid asadzadeh aghdae
اکرم ابوترابی | akram aboutorabi
دکتر محمدرضا زالی | mohammad reza zali
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| نشانی اینترنتی |
http://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/920 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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