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گوارش، جلد ۲۳، شماره ۱، صفحات ۵۳-۵۷
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عنوان انگلیسی Anti-platelet Therapy and the Risk of Upper Gastrointestinal Bleeding
چکیده انگلیسی مقاله Background: We aimed to determine the effects of anti-platelet drugs use on adverse outcomes in patients with non-variceal upper gastrointestinal bleeding (UGIB). Materials and Methods: A historical cohort study was performed on patients with non-variceal UGIB admitted to a tertiary care hospital. Clinical outcomes were compared among users of aspirin and patients who did not receive aspirin. Adverse outcome variables consisted of re-bleeding, need for surgery, and death. Results: Out of 271 patients (77.5% men, mean age 59.5±19.0 years) with non-variceal UGIB, 157 (57.9%) did not receive any anti-platelet drugs, 87 (32.1%) received only aspirin, and 27 (10.0%) received dual anti-platelet therapy. The frequency of adverse outcomes was significantly higher in patients who bled while not receiving anti-platelets (31.2% no anti-platelets, 12.6% single anti-platelet agent, and 14.8% on dual anti-platelets, p =0.002). A significant difference in the duration of admission was not found between the three groups (5.5±4.3 in patients with no anti-platelet drugs, 5.6±4.6 in patients received single anti-platelet agent, and 5.0±4.3 in patients received dual anti-platelets, p =0.84). Conclusion: Patients with non-variceal UGIB while taking anti-platelet drugs had a lower rate of adverse outcomes compared with non-users of anti-platelets.
کلیدواژه‌های انگلیسی مقاله Antiplatelet therapy, Gastrointestinal bleeding, Endoscopy
نویسندگان مقاله | Anahita Sadeghi
Department of internal medicine, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Biglari
Department of internal medicine, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran


| Farhad Fayaz
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Tel: 00982182415104


| Ali Ali Asgari


نشانی اینترنتی http://govaresh.org/index.php/dd/article/view/1884
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/141/article-141-890822.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Brief Report
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