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Caspian Journal of Internal Medicine، جلد ۷، شماره ۲، صفحات ۷۸-۸۱
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Addition of clidinium-C to the 14-day proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication
چکیده انگلیسی مقاله Background: Triple therapy with a proton pump inhibitor and two antibiotics in Helicobacter pylori (HP) eradication is widely accepted, but this combination fails in a considerable number of cases. The aim of this study was to assess the effect of clidinium-C addition on HP eradication and to investigate the efficacy and safety of clidinium-C in prevention of drugs' side effects. Methods: A total of 200 histopathologically confirmed HP positive peptic ulcer enrolled in this study which were randomly assigned to two treatment groups: OAC (20 mg omeprazole bid, 1000 mg amoxicillin bid and 500 mg clarithromycin bid) and OAC + clidinium-C. The effect of treatment and adverse effects were compared 6 weeks after completion of treatment. A13C-urea breath test was performed to confirm HP eradication. Results: A total of 184 patients (90 in group A and 94 in group B) completed the treatment protocols. HP eradication was achieved in 71.1% in OAC versus 72.3% in OCA+clidinium-C, (P=0.73). The frequencies of abdominal pain and stool abnormality, among the side effects recorded during the therapy period, were significantly lower in group B (OCA+clidinium-C) (P=0.01 and P=0.001, respectively). Conclusion: Addition of clidinium-C to OCA triple therapy decreases abdominal pain and frequency of stool abnormalities without affecting HP eradication rate. Based on these findings addition of clidinium-C may increase patient's compliance.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمدرضا سید مجیدی | mohammadreza seyyedmajidi
gastroenterologist, golestan research center of gastroenterology and hepatology-grcgh, gorgan, iran


صبا homapoor | saba homapoor
gastroenterologist, golestan research center of gastroenterology and hepatology-grcgh, gorgan, iran


الهه زنگنه | elahe zanganeh
gastroenterologist, golestan research center of gastroenterology and hepatology-grcgh, gorgan, iran


محمد دادجو | mohammad dadjou
gastroenterologist, golestan research center of gastroenterology and hepatology-grcgh, gorgan, iran


شهاب اسکندری نژاد | shahab eskandari nejad
gastroenterologist, golestan research center of gastroenterology and hepatology-grcgh, gorgan, iran


محمد هادی تاجیک galayeri | mohammad hadi tajik galayeri
gastroenterologist, golestan research center of gastroenterology and hepatology-grcgh, gorgan, iran


جمشید وفایی منش | jamshid vafaeimanesh
qom, shahid beheshti bullward, shahid beheshti hospital, clinical research development center.
نشانی اینترنتی http://www.caspjim.com/browse.php?a_code=A-10-38-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Gastroentrology
نوع مقاله منتشر شده Original Article
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