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International Journal of Fertility and Sterility، جلد ۱۲، شماره ۳، صفحات ۲۲۳-۲۲۸
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عنوان انگلیسی Hypothalamic KiSS1/GPR54 Gene Expressions and Luteinizing Hormone Plasma Secretion in Morphine Treated Male Rats
چکیده انگلیسی مقاله Objective: The inhibitory effects of Morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on GnRH/LH release. Hypothalamic kisspeptin is involved in relaying the environmental and metabolic information to reproductive axis. In the present study the role of kisspeptin/GPR54 signaling system was investigated on relaying the inhibitory effects of morphine on LH hormone secretion. Materials and methods: : In the experimental present study, fifty five Wistar male rats weighing 230-250g in 11 groups (in each group n=5) received saline, kisspeptin(1nmol), P234(1nmol), morphine(5mg/kg), naloxone (2mg/kg), kisspeptin/P234, morphine/naloxone, kisspeptin/morphine, kisspeptin/naloxone, P234/morphine or P234/naloxone respectively. Blood samples were collected via tail vein. Mean plasma LH concentrations and mean relative KiSS1or GPR54 mRNA levels were determined by RIA and RT-PCR respectively. Results: Morphine caused a significant decrease in mean LH concentration, mean relative KiSS1 gene expressions and a non- significant decrease in mean relative GPR54 gene expressions compared to saline. Naloxone caused a significant increase in mean LH concentration and mean relative KiSS1 gene expressions and a non- significant increase in mean relative GPR54 gene expressions compared to saline. Co- administration of kisspeptin/morphine increased significantly mean LH concentration compared to saline or morphine. Co- administration of kisspeptin/morphine decreased significantly mean LH concentration compared to kisspeptin. Co-administration of kisspeptin/naloxone increased significantly mean LH concentration compared to saline or naloxone. Co- administration of P234/morphine decreased mean LH concentration significantly compared to saline. Conclusion: Down regulation of Kiss1 gene expression may be partly involved in the mediating the inhibitory effects of morphine on reproductive axis.
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نویسندگان مقاله | Homayoun Khazali


| Fariba Mahmoudi


| Mahyar Janahmadi


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5332
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-878054.pdf
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