Iranian Journal of Immunology، جلد ۲، شماره ۲، صفحات ۹۷-۱۰۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Lack of Association between ctla-4 A49G Polymorphism and Vitiligo
چکیده انگلیسی مقاله Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology. Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients. Methods: The A49G polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 101 patients and 208 normal healthy age/ethnicity matched individuals. Results: The frequencies of heterozygote genotypes in patients and controls were found to be 42 (41.6%) of 101 and 85 (40.9%) of 208, respectively. The frequencies of homozygote A and G genotypes were 49 (48.5%) and 10 (9.9%) in 101 patients, whereas, these frequencies in 208 control individuals were 103 (49.5%) and 20 (9.6%), respectively. There was no significant difference between the genotype (P = 0.98) and allele (P = 0.86) frequencies of A49G polymorphism in patients and normal healthy individuals. Conclusion: Our results indicate that in contrast to several immune mediated disorders, there is no association between ctla-4 A49G gene polymorphism and vitiligo.
کلیدواژه‌های انگلیسی مقاله Autoimmune,ctla-4,Melanocyte,PCR-RFLP,Polymorphism,Vitiligo
نویسندگان مقاله محمد جواد فتاحی | mohammad javad
department of immunology

عبدالمحمد پزشکی | abdul mohammad
shiraz institute for cancer research

مریم عماد |
department of dermatology, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمد حسین لهراسب | mohammad hosein
department of immunology and

عذرا شمس الدین |
dermatology, fasa medical school, fasa, iran

عباس قادری |
department of immunology

مهرنوش doroudchi |
department of immunology

نشانی اینترنتی http://iji.sums.ac.ir/article_16847_dc8e8917d4a865f01b88f08c1a3672e1.pdf
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