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Iranian Journal of Immunology، جلد ۵، شماره ۴، صفحات ۲۰۱-۲۰۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival |
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| چکیده انگلیسی مقاله |
Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. Objective: The aim of current investigation was to study the impact of polymor-phisms of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I on renal allograft survival. Methods: Using PCR and PCR-RFLP methods in 84 renal transplant recipients, the influ-ence of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. Rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years. Results: Significant reductions were found in the risk of renal transplant rejection in recipients possessing the CCR2-64I (A) allele (p=0.03) or 59029-A allele (p=0.03) compared to non-rejector group. There were no significant differences in the fre-quency of CCR5Δ32 polymorphism in rejector group compared to non-rejector group (p>0.05). Conclusion: It was possible to conclude that the chemokine receptors CCR2-V64I (A) and CCR5- 59029 A alleles may influence renal allograft survival. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
میرداوود عمرانی | mir davood
department of genetics
محمدرضا مختاری | mohammad reza
department of urology and nephrology, uromia university of medical science, uromia, iran
علی tagizadae |
department of urology and nephrology, uromia university of medical science, uromia, iran
مرتضی باقری |
department of genetics
پدرام جمال | ahmad poor
department of urology and nephrology, uromia university of medical science, uromia, iran
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| نشانی اینترنتی |
http://iji.sums.ac.ir/article_17168_1066b530d3351e6f703eff7806258336.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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