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Iranian Journal of Immunology، جلد ۵، شماره ۴، صفحات ۱۸۹-۲۰۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Immunologic Basis and Immunoprophy-laxis of RhD Induced Hemolytic Disease of the Newborn (HDN) |
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| چکیده انگلیسی مقاله |
RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody mediated immune sup-pression (AMIS). Despite the increasing efficiency of treatment, the mechanism of ac-tion of anti-D is not completely defined. There is a widespread interest in obtaining a reliable therapeutic monoclonal anti-D, due to difficulty of maintaining a pool of high titer volunteer donors for plasma collection and also increasing demand for antenatal prophylaxis and safety issues with plasma derived products. Candidate monoclonal anti-D preparations should demonstrate appropriate functionality in both in vitro and in vivo assays comparable to polyclonal anti-D immunoglobulin. These criteria are reviewed in addition to the factors regulating development of D specific immune response in D negative individuals and its suppression in HDN prophylaxis. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
رویا پیام خواجه پاشا | roya payam khaja pasha
stemcore laboratories, sprott centre for stem cell research, ottawa health research institute, ottawa, canada
فاضل شکری |
department of immunology, school of public health, tehran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://iji.sums.ac.ir/article_17167_30457358341b4b7242b61db8f17e1e74.pdf |
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| زبان مقاله منتشر شده |
en |
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