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Iranian Journal of Immunology، جلد ۷، شماره ۴، صفحات ۲۵۲-۲۵۶
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عنوان انگلیسی Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy
چکیده انگلیسی مقاله Background: Spondyloarthropathies are a group of closely related inflammatory arthritis which involve the axial skeleton and are negative for rheumatoid factor. Objective: This case-control study was conducted to examine HLA- B27 positivity in patients with seronegative spondyloarthritis (SSA) as per ESSG criteria and compare the frequency with healthy controls because a lower positivity is reported in Indians. Method: The study included 453 patients and 200 controls. HLA -B27 typing was done by microlymphocytoxicity and/or by sequence specific primers (SSP) using commercial kits. Patients were categorised as Ankylosing Spondylitis (AS), Undifferentiated Spondyloarthropathy, SSA with inflammatory bowel disease, reactive arthritis, psoriatic arthritis and juvenile spondyloarthropathy. Results: HLA-B27 antigen was present in 56% of patient and 3.5% controls with highest frequency in juvenile spondyloarthropathy (80%), followed by AS (76%). The P value < 0.001 for all categories of SSA and overall Odds ratio was 34.9. Conclusion: This study showed HLA-B27 frequency slightly lower than reported in Caucasian SSA patients and in our opinion HLA- B27 testing is extremely useful in young patients with suspected SSA.
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نویسندگان مقاله mahendra narain میشرا | mahendra narain
department of pathology, command hospital sc

vinay singai |
department of internal medicine and rheumatology, command hospital sc , pune, india

نشانی اینترنتی http://iji.sums.ac.ir/article_17066_0b3dd8f8574abbf5ebf814c3a5e867c9.pdf
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