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Iranian Journal of Immunology، جلد ۸، شماره ۱، صفحات ۵۲-۵۷
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عنوان انگلیسی Antineutrophil Cytoplasmic Antibodies in Patients with Pulmonary Tuberculosis
چکیده انگلیسی مقاله Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic syndromes. Multiple studies investigated ANCA positivity in diseases other than small vessel vasculitis. Objective: This study was performed to determine the prevalence of ANCA in pulmonary tuberculosis (TB) which may lead to the false diagnosis of Wegener's granulomatosis (WG) or vice versa. Methods: In a case-control study, 32 consecutive smear positive pulmonary TB patients and 32 normal individuals were studied. All cases and controls were screened for ANCA by indirect immunofluorescent assay (IIF), and MPO and PR3 were also tested by ELISA. Results: A prenuclear pattern (PANCA) was detected in 25% of the cases and 6.25% of the controls and a cytoplasmic pattern (C-ANCA) was deserved in 3.1% of both the cases and the controls by IIF assay. ANCA specificities tested by ELISA in cases revealed that 75% of the cases had anti-MPO and 12.5% had anti-PR3, while in the in controls, 3.12% had anti-MPO and none had anti-PR3. The positive ANCA significantly correlated with TB (p
کلیدواژه‌های انگلیسی مقاله Antineutrophil Cytoplasmic Antibody,Myloperoxidase Antibody
نویسندگان مقاله رویا sherkat |
isfahan university of medical sciences, infectious disease research center, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

کامیار مصطفوی زاده |
isfahan university of medical sciences, infectious disease research center, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

لاله زیدآبادی |
isfahan university of medical sciences, infectious disease research center, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پریسا شعاعی |
isfahan university of medical sciences, infectious disease research center, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سودابه رستمی |
isfahan university of medical sciences, infectious disease research center, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://iji.sums.ac.ir/article_16888_c64f9339bd2072206ef9c6adf4634098.pdf
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