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Iranian Journal of Immunology، جلد ۱۱، شماره ۳، صفحات ۱۳۹-۱۵۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction |
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| چکیده انگلیسی مقاله |
Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To evaluate the frequency of CD4+CD25+CD127- and CD3+CD8+CD28- regulatory T cells in chronic allograft dysfunction (CAD) and to investigate the expression of TGF- β1 in renal allografts. Methods: Thirty biopsy-proven CAD patients were pair-matched with 30 stable graft function patients and a third group of healthy volunteers. Flowcytometry was performed on PBMCs to determine the frequency of CD3+CD8+CD28- and CD4+CD25+CD127- regulatory T cells in lymphocyt population. TGF- β1 gene expression was assessed by Real Time PCR. Results: The percentage of CD3+CD8+CD28- Tregs among renal allograft recipients was higher than healthy controls (p |
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| کلیدواژه‌های انگلیسی مقاله |
Chronic Allograft Dysfunction,Regulatory T Cells,TGF-β1 |
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| نویسندگان مقاله |
سارا assadiasl |
department of immunology, school of medicine
پدرام احمدپور |
chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
محسن نفر |
chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
محبوب دکتر محبوب لسان پزشکی | lessan pezeshki
nephrology research center, tehran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
فاطمه پوررضاقلی |
chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
محمود پروین |
department of pathology, labbafinejad hospital, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
آبتین شهلایی |
molecular immunology research center, tehran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
عادل سپنج نیا |
department of immunology, school of medicine
محمد حسین نیکنام | mohammad hossein
department of immunology, school of medicine
علی اکبر امیرزرگر |
department of immunology, school of medicine
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| نشانی اینترنتی |
http://iji.sums.ac.ir/article_16775_55ff8f8fc06faf95c2f270f4622a0b6f.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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