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Iranian Journal of Immunology، جلد ۱۱، شماره ۴، صفحات ۲۵۹-۲۶۸

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عنوان انگلیسی Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients
چکیده انگلیسی مقاله Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) levels. Additionally, IL-8 levels were determined through ELISA. Results: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p
کلیدواژه‌های انگلیسی مقاله Bead Array,Cytokine,Dysplasia,HNSCC,Larynxm Carcinoma

نویسندگان مقاله mete eyigor |
akdeniz university medical faculty, department of medical microbiology

hulya eyigor |
department of ent head and neck surgery, antalya education and research hospital

ustun osma |
department of ent head and neck surgery, antalya education and research hospital

mustafadeniz یلماز |
department of ent head and neck surgery, antalya education and research hospital

nuray erin |
akdeniz university medical faculty, department of medical pharmacology

omer tarik selcuk | omer tarik
department of ent head and neck surgery, antalya education and research hospital

cem sezer |
department of pathology, antalya education and research hospital, antalya, turkey

مرال gultekin |
akdeniz university medical faculty, department of medical microbiology

سعدی koksoy |
akdeniz university medical faculty, department of medical microbiology


نشانی اینترنتی http://iji.sums.ac.ir/article_16786_c6e88da9f558d773a7abdfd40659951d.pdf
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