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Iranian Journal of Immunology، جلد ۱۱، شماره ۴، صفحات ۲۴۶-۲۵۸
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عنوان انگلیسی Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio
چکیده انگلیسی مقاله Background: Atrial Fibrillation (AF) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. A role for inflammation in the atrial remodeling as well as development and recurrence of AF is known. Objective: To compare IL-17A between patients with different types of AF and healthy individuals. Methods: IL-17A was measured in sera of 112 patients and 107 healthy age/sexmatched controls using ELISA assay. In sera of 26 patients with elevated IL-17A (>1 Pg/ml), CCL5 and CCL18 levels were also measured. Results: IL-17A was significantly increased in patients with AF compared to controls (1.28 ± 3.5 vs. 0.19 ± 0.64 Pg/ml, p=0.001). There was no significant difference in the level of IL-17A between different types of AF. IL-17A was significantly higher in patients with a history of coronary artery bypass graft compared to other patients (p=0.01). A significant positive correlation between IL-17A and CCL18 concentration was found (p=0.001). An increase in the Neutrophil/Lymphocyte ratio (NLR) was observed in patients with elevated serum IL-17A compared to other patients (p=0.006). Male patients showed higher increase in NLR (p=0.007) which was accompanied by a decrease in CCL5 (p=0.000) and a marginal increase in CCL18 (p=0.085) compared to females. There was an increase in CCL5 levels in patients receiving Acetylsalicylic Acid (ASA) therapy (p=0.046). Conclusions: The increase in IL-17A levels is related to the AF pathology mediated by neutrophils and monocytes. The current study signifies the role of immune cells and cytokines in the pathology of AF.
کلیدواژه‌های انگلیسی مقاله Atrial Fibrillation,CABG,CCL5,CCL18,IL-17A,Neutrophil
نویسندگان مقاله محمد حسین نیکو | mohammad hossein
cardiovascular research center

سید رحمت الله تقویان | seyed rahmatollah
department of cardiology

حسین golmoghaddam |
department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نرگس arandi |
department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

علیرضا عبدی اردکانی | alireza abdi
department of cardiology

مهرنوش doroudchi |
department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://iji.sums.ac.ir/article_16785_3911cabf08db3f52973797f0e20f9b42.pdf
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