Iranian Journal of Immunology، جلد ۱۲، شماره ۱، صفحات ۶۴-۶۹
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Adverse Effect of T-2 Toxin and the Protective Role of Selenium and Vitamin E on Peripheral Blood B lymphocytes
چکیده انگلیسی مقاله Background: T-2 mycotoxin belongs to the Trichothecene family and has damaging effects on the immune system. Objective: To investigate the toxic effect of T-2 toxin on the percentage of peripheral blood B lymphocytes and the potential protective role of selenium and vitamin E. Method: Frequencies of B lymphocytes (CD19+ ) were analyzed after injection of sublethal doses of T-2 toxin into Balb/c mice at different time points, using flowcytometry. Additionally, the effects of selenium and vitamin E on B lymphocyte, as either prophylaxis or simultaneously administered with T-2 toxin, were investigated. Results: After injection of a sublethal dose of T-2 toxin, the number of B cells (CD19+ ) significantly decreased at 12 h and became normal at 72 h. When selenium was injected both 24 h before and simultaneously with T-2 toxin, it was able to inhibit B lymphocyte (CD19+) reduction. In contrast, injecting vitamin E, 24 h before or simultaneously with T-2 toxin did not regulate B lymphocyte alteration. Conclusion: Selenium plays pivotal role on altered B lymphocyte subset induced by T-2 toxin comparing to vitamin E.
کلیدواژه‌های انگلیسی مقاله B Lymphocytes,Flowcytometry,Selenium,T-2 toxin,Vitamin E
نویسندگان مقاله علی احمدی |
applied microbiology research center, baqiyatallah university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نجمه پورساسان |
institute of biochemistry and biophysics, university of tehran
سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

جعفر امانی |
applied microbiology research center, baqiyatallah university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

جعفر سلیمیان |
chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://iji.sums.ac.ir/article_16735_6c68e5eb77d2ba626ff4d677756a545d.pdf
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