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Iranian Journal of Immunology، جلد ۱۳، شماره ۳، صفحات ۱۹۷-۲۰۳
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عنوان انگلیسی Effect of TNF-α Blockade in Gingival Crevicular Fluid on Periodontal Condition of Patients with Rheumatoid Arthritis
چکیده انگلیسی مقاله Background: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. Objectives: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. Method: The periodontal statuses of 36 patients (26 females, 10 males) diagnosed with active RA were evaluated both before and after anti-TNF-α therapy. Gingival index, bleeding on probing (BOP), probing pocket depth (PPD), oral hygiene index (OHI), and levels of TNF-α in gingival crevicular fluid (GCF) were measured at the baseline and 6 weeks after the treatment. Wilcoxon signed ranked test was used for statistical analyses. Results: Based on OHI (p=0.860), the level of plaque control did not change during the study period, but there was a significant reduction in gingival inflammation based on the mean BOP (p=0.049) and GI (p=0.036) before and after 6 weeks of anti-TNF-α therapy. The mean PPD index did not significantly differ at the baseline and 6 weeks after treatment (p=0.126). Conclusion: Anti-TNF-α therapy might have a desirable effect on periodontal conditions and might reduce TNF-α level in GCF of patients with RA.
کلیدواژه‌های انگلیسی مقاله Anti-TNF Alpha,Periodontal Diseases,Rheumatoid Arthritis
نویسندگان مقاله زینب کدخدا |
department of periodontology, school of dentistry

علی اکبر امیرزرگر |
molecular immunology research center, department of immunology, school of medicine

زهرا اسماعیلی |
dentistry research institute

مهدی وجدانیان |
rheumatology research center, school of medicine

سولماز اکبری |
department of periodontics, school of dentistry, tehran university of medical science, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://iji.sums.ac.ir/article_33408_4868e89e4ba865c5cb6b09c21ebfc588.pdf
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