|
|
Anatomical Sciences Journal، جلد ۱۱، شماره ۱، صفحات ۲۵-۳۲
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Could Melissa Officinalis Extract Restore Streptozotocin-Induced Spatial Memory Impairment in Rats? |
|
| چکیده انگلیسی مقاله |
Introduction: Alzheimer disease is a progressive and irreversible neuropsychiatric disorder. Melissa Officinalis improves anxiety and clinical dementia symptoms caused by AD therefore, the purpose of the present study was to evaluate the effect of Mellisa extract on spatial memory deficit induced by STZ in MWM examination of male wistar rats. Methods: In the present study, 112 male wistar rats (220-270g) were used. Spatial learning deficit was induced by bilateral ICV injection of STZ (3mg/kg) via cannula then, the Melissa extract in different doses administrated by gavage and Morris Water Maze for measurement of spatial learning parameters was performed. Results: The results of this study demonstrated that gavage of the 200mg/kg of Melissa officinalis in combination with STZ, followed by significant reduction in two parameters: Time and Distance. Conclusion: Totally, the data indicate possible therapeutic value of M. officinalis extract on spatial learning improvement. |
|
| کلیدواژه‌های انگلیسی مقاله |
STZ, Melissa Officinalis, Spatial Memory |
|
| نویسندگان مقاله |
فاطمه sabbaghziarani | fatemeh sabbaghziarani
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
شراره rasapour | sharareh rasapour
school of biological sciences, khwarizmi university
کیوان مرتضایی | keywan mortezaee
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
شهربانو عریان | shahrbano oryan
school of biological sciences, khwarizmi university
محمد شریف زاده | mohammad sharifzadeh
department of pharmacology, school of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مهناز خانوی | mahnaz khanavi
department of pharmacology, school of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
غلامرضا حسن زاده | gholamreza hassanzadeh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
|
|
| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-57-1&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|